The Cardinals hold a 1-0 lead over the San Diego Padres through five innings at Busch Stadium.
Jason Heyward led off the bottom of the fifth with a single, and Yadier Molina moved Heyward to third on a hit-and-run into left field.
San Diego pitcher Andrew Cashner then walked Randal Grichuk on a 3-2 pitch. Xavier Scruggs grounded into a double play, but Heyward scored from third.
Tommy Pham, making his 2015 major league debut, grounded out to end the inning.
Cards-Padres scoreless through four innings
Through four innings, the St. Louis Cardinals and San Diego Padres are scoreless in their Friday night match-up at Busch Stadium.