Everton face a selection headache in attack, with Dominic Calvert-Lewin and Moise Kean both doubts due to injury.
Jean-Philippe Gbamin will be assessed for a minor injury, while Richarlison may not be risked after missing pre-season because he played in the Copa America and Olympics.
Southampton have no new injury concerns, with James Ward-Prowse available following a knee problem.
Sam McQueen and Will Smallbone remain long-term absentees.
LAWRO'S PREDICTION
This is a big game for Everton because it's Rafa's first as manager, and the crowds are back. There are going to be people there who don't want him in charge but he is a very good manager, and I'm expecting him to start the season with a win.