Chelsea captain Gary Cahill has returned to training after gastroenteritis and could be involved against Southampton on Tuesday.
Head coach Antonio Conte is likely to recall Diego Costa and Eden Hazard after leaving them out for the FA Cup semi-final win over Tottenham.
Southampton midfielder Oriel Romeu is available to face his former side after completing a two-match ban.
Sam McQueen is set to miss the fixture because of a minor groin strain.
Long-term absentees Matt Targett and Charlie Austin will return to training later this week.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "This is huge.