Burnley midfielder Ashley Westwood is awaiting scan results on the serious ankle injury he sustained during the draw at West Ham last weekend.
Captain Ben Mee, Erik Pieters and Johann Berg Gudmundsson are set to stay sidelined by injury until May.
Southampton's only absentee is goalkeeper Alex McCarthy, who remains out with a hamstring problem.
Mohammed Salisu and Tino Livramento are among those in contention to return should Southampton rotate their squad.
MATCH FACTS
Head-to-head
- Southampton ended a run of seven league games without a win at Burnley last season, courtesy of a fifth-minute goal by Danny Ings.