UEFA Euro 2016 qualifying campaign against Belarus. However, some key injuries in midfield coupled with a long and daunting trip could cause problems for manager Vicente del Bosque's talented squad.
Del Bosque is taking charge of his 100th game as national team manager, according to the English arm of Catalan publication Sport. He has big choices to make both in midfield and along the forward line.
Here are all of the relevant schedule and viewing details:
Date: Sunday, June 14
Time: 7:45 p.m. (BST) / 2:45 p.