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Vote: What's the biggest upset so far in the NCAA tournament?

The first few days of the NCAA tournament may have been quiet, but the madness in March started to reveal itself over the weekend.

On Saturday, No. 1 overall seed and defending national champion Villanova was knocked out by eighth-seeded Wisconsin. Then, 11th-seeded Xavier dominated third-seeded Florida State in the Round of 32.

The Michigan Wolverines' hot streak continued, as they topped second-seeded Louisville to win their seventh straight game. Preseason No. 1 Duke, a 2 seed, was stunned by seventh-seeded South Carolina, a game in which the Gamecocks controlled for most of the contest.