San Diego scored five runs, which equaled the club's highest total in Cashner's first nine starts of the season.
Going into the game, Cashner was one of six Major League pitchers since 1920 to have seven losses in their first nine starts with an ERA of under 3.00. He was the first to accomplish the dubious feat since the Mets' Jim McAndrew in 1968.
Before Wednesday night, the Padres had scored three runs for Cashner over his last six starts and his run support average of 2.41 was the sixth-lowest mark in the Major Leagues and the third-worst mark in the National League.