Sep 24, 2022; Norman, Oklahoma, USA; Oklahoma Sooners fans during the game against the Kansas State Wildcats at Gaylord Family-Oklahoma Memorial Stadium. Mandatory Credit: Kevin Jairaj-USA TODAY Sports
The Oklahoma football program has played 422 games against teams currently a part of the Power Five Conferences not named the Big 12 and won 278 or 66 percent of those games.
Of the 55 teams that make up the other four Power Five conferences, Oklahoma has a breakeven or winning record against 40 of them and has never played six of them.
The Sooners have played the most games against teams from the Southeastern Conference (156), but that number is skewed because Missouri and Texas A&M are former members of the Big 12.