The 15 League Cup groups have been set consisting of all 47 clubs, 18 from Liga MX and 29 from the MLS. Each region will have four different groups except for the West which will only have three.
Two teams will not have to play in the group stage and get an automatic bye to the round of 32. LAFC which was the MLS Cup champion in 2022 and Pachuca which was the Liga MX champion and had the most combined points across the Clausura and Apertura seasons in 2022. The remaining teams in the MLS and Liga MX (Clausura and Apertura) have been placed in their groups by their performance in 2022 and their geographic region.