The Twins can't lose too many games in September like the one they lost Thursday if they hopes to play in the postseason.
The Twins (69-64) built a 4-1 lead on Eddie Rosario's fourth-inning grand slam, but the White Sox scored the final five runs to win 6-4 at Target Field in front of the 25,339 in attendance and avoid a series sweep.
Twins starter Kyle Gibson was serviceable, allowing three runs on five hits in six innings.
But the bullpen couldn't hold Minnesota's advantage. Chicago (62-70) struck for three runs in the seventh, all charged to Casey Fien, to gain a lead it wouldn't relinquish.