Jose Mourinho returns to former club Chelsea with Manchester United on Sunday having struggled to break down Liverpool in the 0-0 draw at Anfield, but seeing his side score four against Feyenoord.
Arsenal are flying high after their demolition of Ludogorets, which was their seventh win in a row in all competitions, and will hope add to that streak against struggling Middlesbrough, while leaders Manchester City take on Southampton hoping to get back on track after their humbling at Barcelona.
Will David Moyes finally win a game as Sunderland boss? And can Everton to push for a place among the big boys at the top of the table?