Mike Conley had 16 points and Courtney Lee added 15 points off the bench but Grizzlies fell to the Spurs on Saturday, 92-82, snapping Memphis' four-game winning streak.
Manu Ginobili added 15 points for San Antonio, which is unbeaten in six home games.
Tim Duncan had 10 points, including a pair of running floaters in the lane in the final 90 seconds to seal the victory, as well as 10 rebounds.
Memphis' only lead came on Tony Allen's 20-foot jumper to open the game.
Neither team had its starting power forward. LaMarcus Aldridge was a late scratch with a sprained left ankle, his first missed game with San Antonio.