Old Dominion gave Marshall their fourth loss in a row at the last game at home on Senior Night.
The Herd started the game by taking a one-point lead in the second quarter. Roshala Scott had a pair of jump shots in the first quarter, and junior guard Abby Beeman had six points in the paint.
Marshall outscored the Monarchs by six points in the second quarter thanks to free throws and layups from Scott and Beeman. Center Mahogany Matthews also added some rebounds to the box score and a layup.
Marshall put up 35 points in the first half, which gave the Herd a seven-point lead.