Our friendly in Las Vegas, which is being shown live on MUTV (02:00 BST, Monday), presents an excellent opportunity for the 23-year-old to show his skills against the Bundesliga outfit, who could hand a debut to Marcel Sabitzer.
Sancho racked up outstanding stats during his time with Dortmund, notching 50 goals and 64 assists in 137 matches for a free-flowing attacking side.
The club's chief executive Hans-Joachim Watzke praised Sancho when completing the deal with United.
"Jadon has behaved fantastically," he said. "He has pushed us forward, also in the second leg of the season, and, accordingly, it is like this just now.