Those are the big questions ahead of matchday five getting underway at the earlier time of 17:45 GMT in Istanbul, Turkey.
Fans who play our United Predictions game should know that the line-ups deadline is 16:30; you then have until kick-off for the First Scorer, Correct Score and Man of the Match categories. Here, you can read what our MUTV pundits are backing...
PHIL BARDSLEY
The former United defender expects two changes to the team, with Antony replacing the suspended Marcus Rashford and Rasmus Hojlund taking the place of Anthony Martial…
Line-up: Onana; Dalot, Maguire, Lindelof, Shaw; McTominay, Mainoo, Fernandes (C); Antony, Hojlund, Garnacho.