As usual, United's possible starting XI is the subject of much conjecture, with Luke Shaw and Raphael Varane missing last weekend's Manchester derby due to Covid, and Edinson Cavani and Cristiano Ronaldo negotiating injury problems.
The highly anticipated team line-up will be released at exactly 16:30 GMT – one hour ahead of kick-off at Old Trafford – and you can get it hot off the press via the United App, ManUtd.com, MUTV and our social channels. Don't forget to make your United Predictions, either, for the chance to win a signed shirt.
Bear in mind that we'll get a further indication on who might be available (or not available) in Friday's traditional pre-match conference.