Manager Erik ten Hag named an unchanged team from the Emirates FA Cup win over Liverpool before the international break but admitted his disappointment with the lack of intensity during the 1-1 draw at Brentford on Saturday.
Amad is definitely available again after serving his one-game ban, following his heroics in the memorable quarter-final tie at Old Trafford, while Harry Maguire, Lisandro Martinez, Casemiro and goalscorer Mason Mount came off the bench at the Gtech Community Stadium.
Antony was also one of the substitutes used by Ten Hag and offers an option on the flanks.