Pujols' homer also gave him 1,800 career RBIs and made him the seventh player in history to reach 1,200 extra-base hits. His homer followed Mike Trout's two-run shot, also off Reds starter Dan Straily. It was Pujols' 47th career homer off Cincinnati pitching.
Pujols added another RBI in the third inning with a double off Straily, driving in Trout.
The only players with more RBIs than Pujols in a 16-year span are Jimmie Foxx (1,879 from 1927-42) and Alex Rodriguez (1,872 from 1996-2011).
The first six players to reach 1,200 extra-base hits were Hank Aaron, Barry Bonds, Stan Musial, Babe Ruth, Willie Mays and Rodriguez.