Before Monday, Tyler Skaggs had started twice against the Detroit Tigers and given up one earned run in 11 2/3 innings.
Then he gave up four on one swing, James McCann hitting a grand slam in the third inning of a 9-3 Angels loss.
"I yanked it, tried to be too careful," Skaggs said of a fastball that caught too much of the strike zone. "I maybe tried to guide in it there. It was the right pitch but not the right spot."
Upton, back in the Angels lineup after sitting out one game because of a contused forearm, went one for four.