The Royals now have lost five of six and 13 of 18, and are fading from playoff contention. The defending-champion Royals have fallen 8 1/2 games behind the American League Central-leading Indians. The Angels snapped a three-game losing streak.
Santiago gave up five hits and walked four but struck out five. Royals starter Ian Kennedy gave up four runs in the first inning and left in the sixth, trailing, 4-2.
MOMENTS THAT MATTERED
RBI Machine: Pujols hit a two-run single up the middle to ignite a four-run first inning, then singled to right in the seventh and added another in the ninth.