A regular member of Michael Beale's U23 squad, the 18-year-old has been called up by Ireland boss Noel King for the matches which both take place in Spain.
The Republic of Ireland U21 squad are in La Manga preparing for the 2019 UEFA U21 European Championship qualifiers.
Ireland play Czech Republic on Saturday November 12 before facing Slovakia on Tuesday November 15.
Whelan, who is equally at home playing at right-back or centre-half, joined Liverpool from Crewe Alexandra as an U10 player.