Royals No. 4 starter Jason Vargas, meanwhile, enjoyed a seven-inning outing. The left-hander allowed two runs on seven hits -- including A's prospect Matt Chapman's third homer of the spring -- while striking out five.
Kansas City posted five runs in a third inning that included a solo shot from Moustakas and a two-run homer off the bat of Orlando. Raul Mondesi, awarded the starting second base job Monday, capped the frame with a two-run double.
Moustakas, Escobar and Lorenzo Cain turned in multi-hit games for the Royals.
Royals up next:The Royals return to Surprise Stadium on Tuesday as right-hander Nathan Karns, the No.