Royals left-hander Danny Duffy retired the first 16 hitters he faced until Avisail Garcia singled sharply to right field. Two more hits loaded the bases for Melky Cabrera, who crushed a grand slam to left field, his third career slam. Todd Frazier followed with a homer and the White Sox had a 5-1 lead.
White Sox starter Miguel Gonzalez took a 5-2 lead into the seventh inning, but he left with a runner on second and one out.