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Indianapolis Colts rule LT Anthony Castonzo, RT Braden Smith out vs. Pittsburgh Steelers

INDIANAPOLIS -- The Colts will be without their two starting offensive tackles for Sunday's game at Pittsburgh.

Starting left tackle Anthony Castonzo was downgraded from questionable to out Saturday due to an ankle injury, the team announced. Starting right tackle Braden Smith was ruled out Friday after being put on the reserve/COVID-19 list.

Colts coach Frank Reich would not divulge who would start at right tackle Friday. Now the Colts have to figure out who will start at both tackles against a Pittsburgh defense that has an NFL-high 47 sacks this season.

There's a possibility that the Colts could slide All-Pro right guard Quenton Nelson to left tackle.