Luton Town inflicted a sixth Championship defeat of the season on Hull City, who sacked manager Shota Arveladze just hours before kick-off.
Andy Dawson was named interim head coach and took charge of the team but they conceded within six minutes through Alfie Jones' own goal.
Regan Slater hit the bar for the hosts as they pressed for an equaliser, but Henri Lansbury struck low from distance for Luton's second before the break.
Hull offered little in response in the second half, as Luton closed out the victory and moved up to fifth in the table.