Houston and Washington have played each other 457 times in regular season play, starting when the Nats were known as the Montreal Expos. Houston owns a 248-209 edge for a .543 winning percentage, their third-best record against a National League team. Of course, the two teams met once in the postseason, but that’s all I’m going to say about that.
The last time these two met was from June 13 through 15 last season at Minute Maid Park. The Astros won the first two games before the Nats salvaged one victory, 4-1 in 10 innings in the finale.