Keuchel (11-2) allowed three hits and one walk and forced the A's into a steady diet of ground-ball outs for his 12th consecutive quality start against Oakland. The Astros (75-47), who began the day with a 12-game lead over the Angels atop the American League West, improved to 18-2 against the A's since July 20, 2016.
Alex Bregman and Jose Altuve hit back-to-back, two-out solo homers off A's starter Sean Manaea (8-8) in the third, and Josh Reddick added a two-out RBI single against his former team in the sixth to push the lead to 3-0.