Being obsessed with signature or good or best wins in college athletics is a bit dumb. Good teams play other good teams fairly often, and a good (or bad!) performance against a great team is often less predictive than a series of excellent or subpar performances against bad teams.
That said: In these sports, subjective judgments are part of the process, and it is better to have more of those wins than not. And so, with Florida getting its best chance at a signature win thus far this season on this Saturday as Michigan State enters the O’Dome (noon, CBS or CBS All-Access), the Gators have a major opportunity before them today.