Florida State owns three straight wins in the episodic rivalry with Notre Dame, but these teams haven't met since 2014 and a lot has changed since then. The undefeated Irish are solid favorites for Saturday night's clash with the Seminoles in South Bend.
College football point spread: The Fighting Irish opened as 18-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 38.3-19.6 Fighting Irish (College football picks on every game)
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