The moves cut Detroit's camp roster to 36 players, with six days to go before the team heads north.
The 33-year-old Lowe was one of the big pieces of the Tigers' bullpen revamp after the 2015 season, signing a two-year, $11 million contract as a free agent during the Winter Meetings. He was coming off an impressive comeback campaign, having posted a 1.96 ERA and 2.57 FIP between Seattle and Toronto in '15.
The Tigers were hoping he could do for their bullpen what Joaquin Benoit did five years earlier, stabilizing the setup role and carrying leads to the closer.