We're with Vegas on this one. Newton will cap his incredible campaign, but won't do it alone. He'll complement the strong play of the Carolina defense, which could generate a couple Manning turnovers. The Broncos defense is good enough to keep it interesting into the fourth quarter, but it won't be enough. Prediction: Carolina 26, Denver 17
Analysis: Peyton Manning threw at least one interception in his first nine games this year. He's posted a clean ledger the past three weeks, including a pair of playoff wins, but he's completing well below 60 percent of his throws.