MEXICO CITY -- The San Francisco 49ers are headed home with a win -- and tied for first in the NFC West -- after defeating the Arizona Cardinals 38-10 at Estadio Azteca on Monday night.
With 78,427 fans in attendance for the NFL's final international game of the season, the Niners (6-4) extended their win streak to three games and leaned heavily on wide receiver Brandon Aiyuk and running backs Deebo Samuel and Christian McCaffrey. The Cardinals fell to 4-7 as backup quarterback Colt McCoy started in place of the injured Kyler Murray for the second consecutive week.