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2022 NFL Draft: Last 25 players selected 25th overall

Unless Buffalo Bills general manager Brandon Beane executes a draft-night trade with pick No. 25 during Thursday’s NFL Draft in Las Vegas, the Bills will make history with their first-round pick.

That’s because, in the history of the draft, the Bills have never picked at No. 25, though the team did hold the 25th selection in the 1961, 1964, and 1966 AFL Drafts.

In fact, their drafting of defensive back Butch Byrd at pick No. 25 in 1964 certainly panned out well for the team, as Byrd played seven seasons in Buffalo’s secondary, appearing in 98 games (97 starts) with five AFL All-Star nods.