Mookie Betts led off the game with a home run and Hanley Ramirez added an RBI single with one out in the first, but Santiago escaped a bases-loaded jam without any further damage, and the Red Sox didn't score again.
Santiago allowed 10 baserunners and threw more than 100 pitches in the first four innings, but somehow managed to complete five innings of two-run ball. Smith then got the Angels into the eighth with a three-run lead by retiring all four batters he faced, giving him 7 2/3 consecutive scoreless innings and lowering his ERA to 3.