Aston Villa's Alex Moreno will require up to three months of rehabilitation following hamstring surgery.
Fellow defenders Diego Carlos and Calum Chambers are available after injury and illness respectively but Philippe Coutinho still isn't fit.
Lewis Dunk could return for Brighton after being rested on Wednesday because of a back issue.
Albion remain without the injured Adam Lallana, Jakub Moder, Jeremy Sarmiento, Solly March and Tariq Lamptey.
CHRIS SUTTON'S PREDICTION
Aston Villa must win or match Tottenham's result at Leeds and hope Brentford don't beat Manchester City to secure a Europa Conference League spot.