Aston Villa are out to improve on their finishing after dominating Sunday's 2-2 draw at home to Nottingham Forest.
Former Walsall boss Dean Smith returns to the West Midlands with Brentford to face the team he supported as a boy.
Defender Rico Henry is out after shoulder surgery, so Andreas Bjelland could fill in at left-back and make his first league start for the Bees.
Defender Callum Elder (gashed knee) is a doubt but forward Lasse Vibe may return after a one-match suspension.
Brentford head coach Dean Smith told BBC Radio London: "It is a game we are all looking forward to on the back of the performance at Brighton on Saturday.