The Gunners' hopes of finishing top of their group were dealt a huge blow following their 2-2 draw with Paris Saint-Germain at the Emirates, which ensured the French club go in to the final round of games in the driving seat.
Given the superior head-to-head record of the Ligue 1 giants, the Gunners need an unlikely helping hand from Ludogorets at the Parc des Princes tonight if Arsene Wenger's side are to clinch first place.
But how important is it to finish top?
Here's who Arsenal could draw in the last 16, based on current standings:
If they finish second: Benfica, Barcelona, Atletico Madrid, Monaco, Borussia Dortmund, Juventus
Here's who are 'definite possible' opposition if Arsenal win Group A (ie.