Arsenal forward Gabriel Martinelli returns after missing Tuesday's draw at PSV Eindhoven because of illness.
Emile Smith Rowe made his comeback from injury as a late substitute in midweek but Mohamed Elneny is ruled out after straining a hamstring in Eindhoven.
Brighton boss Roberto de Zerbi may freshen up his side following Thursday's win against Marseille.
Evan Ferguson, Bart Verbruggen and Carlos Baleba are among those who could return to the starting line-up.
Ansu Fati, Pervis Estupinan, Tariq Lamptey, Julio Enciso and Solly March remain sidelined.
MATCH FACTS
Head-to-head
- Brighton have won five and lost four of their 12 Premier League matches against Arsenal.