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Arizona Wildcats open as significant underdog at USC

The Arizona Wildcats will get another crack at a top-10 team and Heisman candidate quarterback when they face the USC Trojans in Los Angeles this Saturday.

Like their game against Washington, the Wildcats have the odds stacked against them.

Arizona has opened as a 22-point underdog to the Trojans, according to DraftKings Sportsbook. No over/under has been listed.

The game is set to kick off at 7:30 p.m. MST on ESPN.

Arizona is coming off an impressive cover, falling to Washington 31-24 despite being 19-point ‘dogs. The Wildcats are now 4-1 against the spread (ATS) this season, with the only failed cover coming in a 21-20 win at Stanford.