Barcelona star Philippe Coutinho will not return to fitness before the November international break, according to the Brazil national team's medical staff.
Coutinho suffered a hamstring injury in Saturday's defeat to Real Madrid despite completing the full game at Camp Nou.
Barca said a timescale for the former Liverpool man's return "depends on how the injury evolves", but Brazil's doctors have also now assessed the player.
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Doctor Rodrigo Lasmar said in a statement that he believes "there is not enough time for the recovery of the player for his participation in the next two rounds of [2022 World Cup] qualifiers".