Southampton manager Mauricio Pellegrino could start Virgil van Dijk for this first time this season against free-scoring Manchester United on Saturday.
Van Dijk has not started a game for eight months after suffering a serious foot injury in January and handing in a transfer request during the summer.
The Netherlands international made his first-team return as a substitute in the 1-0 win at Crystal Palace last weekend and could now be called upon against a United side with 16 goals in their opening five Premier League games.
"We'll decide tomorrow [Friday]," Pellegrino said when asked whether Van Dijk would play.