Manchester United manager Jose Mourinho has opted for the same team that beat Everton 4-0 last weekend despite the lethargic nature of their win.
Ashley Young continues at left-back with Marouane Fellaini starting in place of the injured Paul Pogba.
Marcus Rashford – fresh from his midweek praise after his showing against Burton Albion – will look to be the driving force alongside Romelu Lukaku.
Many thought Southampton boss Mauricio Pellegrino would hand Virgil van Dijk his first competitive start for the Saints since his summer transfer saga but the defender remains on the bench.