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After a bumper weekend of FA Cup football, the Premier League is back on the domestic calendar in the coming days.
Division leaders Liverpool will be out to continue their relentless march at the top of the table, when they visit a struggling Tottenham Hotspur side on Saturday.
Mikel Arteta will be looking to back up his decent start to life as Arsenal boss earlier in the day, when his team face a potentially tricky contest away at Crystal Palace. Elsewhere, Aston Villa host Manchester City on Sunday.
Here the fixtures in full for Week 22, a prediction for each match and a closer look at a couple of players primed to make a difference in their respective games.