Full guide to Penn State vs. No. 1 Ohio State: How to watch, odds, injuries, and more

Fansided | October 29, 2025

Ohio State comes off its second bye week looking to stay undefeated against a struggling Penn State team.

Ohio State Buckeyes safety Caleb Downs (2) celebrates a tackle of Penn State Nittany Lions tight end Tyler Warren (44) during the second half of the NCAA football game at Beaver Stadium in University Park, Pa. on Saturday, Nov. 2, 2024. Ohio State won 20-13. | Adam Cairns/Columbus Dispatch / USA TODAY NETWORK via Imagn Images

The matchup between Ohio State and Penn State is normally one of biggest matchups of the college football season, but with the Nittany Lions firing James Franklin and being winless in the Big Ten right now, this one is matching up to be another notch on Ohio State's belt.