Jerick McKinnon is once again on the sideline after the San Francisco 49ers placed him on season-ending injured reserve with a knee injury Saturday, according to ESPN's Adam Schefter.
The running back missed the 2018 season with a torn ACL and was out most of camp with knee problems, so the 49ers are more than comfortable playing without him.
San Francisco has two other quality options in the backfield who can pick up the slack in Tevin Coleman and Matt Breida, both of whom can be viable fantasy players going forward.