Mackenzie Blackwood made 38 saves as the Devils beat the Penguins 2-1 on Friday night at the Prudential Center in Newark.
Travis Zajac and Blake Coleman scored for the Devils.
Jack Johnson scored for Penguins, and Matt Murray made 19 saves.
It was Pittsburgh’s first game without star center Sidney Crosby, who is expected to miss at least six weeks following surgery for a core muscle injury.
Zajac scored the only goal of the opening period at 6:59, converting a setup in the slot from Jesper Bratt.
The goal ended a 10-game point drought for Zajac, the longest in the veteran center’s career.