Clemson defeated Syracuse four times in a row following the latter's entry into the ACC, but the Orange shocked the Tigers last year with a big upset. Syracuse is also 3-1 against the spread over the last four meetings in this series. Who's the smart bet for Saturday afternoon's battle?
College football point spread: The Tigers opened as 20-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 46.8-19.4 Tigers (College football picks on every game)
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