The Reds are looking to build on successes over West Brom, domestically, and Istanbul Basaksehir, in the Champions League, since returning from the international break.
Victory at St Mary's would secure a club record run of eight successive top-flight wins but the home side have enjoyed a marvellous start to the campaign, with Ralph Hasenhuttl's men sitting fifth in the table after briefly topping the division.
Scott McTominay and Paul Pogba did not train on Friday and could well be unavailable again - both missed the win over Istanbul and this would represent a third game out for Pogba since he was involved in France's UEFA Nations League ties.