Europe's premier competition returned to Old Trafford, albeit without any fans present of course, and Ole Gunnar Solskjaer's side put on a real show.
Mason Greenwood's slick 21st-minute finish was the difference between the sides in the first half.
After the break, Substitute Marcus Rashford scored twice before Anthony Martial got in on the act with a penalty.
Rashford then sealed his first senior hat-trick with a firm finish from a Martial pass.
Watch the highlights of a memorable evening in the video at the top of the page and check out more post-match reaction from the manager and players below.