All eyes are on new manager Erik ten Hag and his team selection, after an intriguing pre-season schedule and a summer transfer window that has, to date, brought three new faces to Old Trafford.
The Dutchman is likely to provide a detailed update on his squad's health and general readiness on Friday (5 August), when he sits down with the media for his pre-match press conference at Carrington.
But here's what we already know...
There was good news on Wednesday, when Luke Shaw was pictured in training, after missing both the Atletico Madrid and Rayo Vallecano games last weekend.